Mammals Can Delay The Development of Their Embryos, According to Recent Research

Recent research sheds light on something quite peculiar, exploring a reproductive mystery that is present in more than 130 species of mammals. A team of researchers conducted by Abdiasis Hussein, an associate director of UW Medicine’s Institute for Stem Cell, also a UW professor of biochemistry, realized the intriguing findings on mammals.

The results not only bring more details for the understanding of postponed embryo implantation. It also indicates how some quickly splitting cells, such as those present in tumors, turn to be inactive.

A Case of Postponed Embryo Development in Mammals

To find out what leads to a biochemical hold-and-release on embryonic production, the team provoked diapause in a female mouse by decreasing the estrogen rates. Then, they realized a comparison of the diapause embryos to pre-implantation and post-implantation ones. They also provoked diapause in mouse embryonic stem cells by weakening the cells, and analyze those to actively developing mouse embryonic stem cells.

Researchers had also performed comprehensive investigations of how metabolic and signaling pathways manage both the inactive and active phases of mouse embryos and mouse embryonic stem cells in lab vessels.

Metabolism involves the life-supporting chemical actions cells take out to turn substances into energy, develop materials, and discharge waste. By examining those reactions’ final actions, dubbed metabolites, the researchers could start to realize the full picture of that occurs to cause diapause and how cells are delivered from its grips.

Bears, seals, weasel-like animals, or armadillos, experience seasonal diapause, as a regular part of their reproductive periods. Many classes of bears, for example, breed in the early stages of spring and sometimes even in early summer. The female then uncontrollable hunts for food, and only when it reaches sufficient weight and body fat, one or more of her embryos implant a few months later after she moves to her cave. Any baby bears would be born in late winter.

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